Journal article
Measurement of fecal calprotectin improves monitoring and detection of recurrence of Crohn's disease after surgery
EK Wright, MA Kamm, P De Cruz, AL Hamilton, KJ Ritchie, EO Krejany, S Leach, A Gorelik, D Liew, L Prideaux, IC Lawrance, JM Andrews, PA Bampton, SL Jakobovits, TH Florin, PR Gibson, H Debinski, FA Macrae, D Samuel, I Kronborg Show all
Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2015
Abstract
Background & Aims Crohn's disease (CD) usually recurs after intestinal resection; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence. We investigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis of the mucosa. Methods We analyzed data collected from 135 participants in a prospective, randomized, controlled trial, performed at 17 hospitals in Australia and 1 hospital in New Zealand, that assessed the ability of endoscopic evaluations and step-up treatment to prevent CD recurrence after surgery. Levels of FC, serum levels of C-reactive protein (CRP), and Crohn's disease activity index (CDAI) scores were ..
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Funding Acknowledgements
Research support was provided by the St Vincent's Research Endowment Fund; Smart-Prep testing kits were provided by Bulhmann; and supported by the National Health and Medical Research Council (E.W., P.D.C., and M.A.K.).