Early exercise after spinal cord injury ('Switch-On'): study protocol for a randomised controlled trial
Mary P Galea, Sarah A Dunlop, Ruth Marshall, Jillian Clark, Leonid Churilov
TRIALS | BMC | Published : 2015
BACKGROUND: Spinal cord injury (SCI) leads to a profound muscular atrophy, bone loss and bone fragility. While there is evidence that exercising paralysed muscles may lead to reversal of muscle atrophy in the chronic period after SCI, there is little evidence that exercise can prevent muscle changes early after injury. Moreover, whether exercise can prevent bone loss and microarchitectural decay is not clear. METHODS/DESIGN: A multi-centre, parallel group, assessor-blinded randomised controlled trial will be conducted. Fifty participants with acute spinal cord injury will be recruited from four SCI units in Australia and New Zealand. Participants will be stratified by site and AIS status and..View full abstract
Funding from the Transport Accident Commission (Victorian Neurotrauma Initiative) and the National Health and Medical Research Council of Australia.