Chorioamnionitis occurring in women with preterm rupture of the fetal membranes is associated with a dynamic increase in mRNAs coding cytokines in the maternal circulation

O Stock; L Gordon; J Kapoor; SP Walker; C Whitehead; TJ Kaitu'U-Lino; G Pell; NJ Hannan; S Tong

Journal article

Chorioamnionitis occurring in women with preterm rupture of the fetal membranes is associated with a dynamic increase in mRNAs coding cytokines in the maternal circulation

O Stock, L Gordon, J Kapoor, SP Walker, C Whitehead, TJ Kaitu'U-Lino, G Pell, NJ Hannan, S Tong

Reproductive Sciences | SAGE PUBLICATIONS INC | Published : 2015

DOI: 10.1177/1933719114565034

Abstract

Background: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of preterm birth, particularly in the setting of chorioamnionitis. No sensitive or specific diagnostic or predictive test currently exists for the accurate diagnosis of chorioamnionitis. Our aim was to measure messenger RNA (mRNA) coding cytokines in the maternal blood and examine whether they were increased in association with chorioamnionitis at delivery. Methods/Results: We performed a prospective cohort study of women recruited with PPROM at a mean gestational age of 28.9 weeks at risk of developing chorioamnionitis. Blood was sampled from participants, and the ..

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University of Melbourne Researchers

Susan Walker Author

Clare Whitehead Author

Tu'uhevaha Kaitu'u-Lino Author

Natalie Hannan Author

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Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Grant Support: This study was supported by the Medical Research Foundation for Women and Babies. The National Health and Medical Research Council of Australia provided scholarship; OS #1055795 and salary support; TKL #1062418, NJH #628927 and ST #1050765.