Journal article
Orexin/hypocretin role in reward: Implications for opioid and other addictions
C Baimel, SE Bartlett, LC Chiou, AJ Lawrence, JW Muschamp, O Patkar, LW Tung, SL Borgland
British Journal of Pharmacology | Published : 2015
DOI: 10.1111/bph.12639
Abstract
Addiction is a devastating disorder that affects 15.3 million people worldwide. While prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential target for anti-craving medications. Orexins, also known as hypocretins, are neuropeptides produced in neurons of the lateral and dorsomedial hypothalamus and perifornical area, which project widely throughout the brain. The absence of orexins in rodents and humans leads to narcolepsy. However, orexins also have an established role in reward seeking. This review will discuss some of the original studies describing the roles of the orexins in reward seeking as well as specific works that were presented at the 2013 I..
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Awarded by National Science Council Taiwan
Funding Acknowledgements
A. J. L. is a NHMRC Principal Research Fellow and supported by project grants from the NHMRC and ARC, the Pratt & Besen Family Trusts, and the Victorian Government's Operational Infrastructure Support Program. This mini-review discusses primarily the findings from past and present Lawrence laboratory members, all of whom are much appreciated. L. C. C. is supported by grants from the National Science Council, Taiwan (NSC 101-2325-B002-048 and NSC 102-2321-B002-066) and the National Health Research Institutes, Taiwan (NHRI-EX102-10251NI). S. E. B. is supported by funding from the Australian Research Council Future Fellowship and NHMRC. J. W. M. is supported by USPHS Grants, NIH F32-DA026250 and K99-DA031767. C. B. is supported by a Brain Canada Predoctoral Fellowship, S. L. B is supported by a CIHR New Investigator Award and an NSERC 372517.