A ghrelin receptor agonist is an effective colokinetic in rats with diet-induced constipation
RV Pustovit, JB Furness, LR Rivera
NEUROGASTROENTEROLOGY AND MOTILITY | WILEY-BLACKWELL | Published : 2015
BACKGROUND: Despite constipation being a common problem, the treatments that are available have side effects and are only partly effective. Recent studies show that centrally penetrant ghrelin receptor agonists cause defecation in humans and other species. Here, we describe some features of a rat model of low fiber-induced constipation, and investigate the effectiveness of the ghrelin agonist, capromorelin. METHODS: Rats were given low-fiber diets for 5 weeks. Their colorectal responsiveness to distension and to a behavioral test, water avoidance and colon histology were compared to those of rats on a standard diet. KEY RESULTS: After the low-fiber diet, distension of the colon produced fewe..View full abstract
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Awarded by National Health and Medical Research Foundation of Australia
This research received funding from the Transport Accident Commission, through the Institute for Safety, Compensation and Recovery Research, and the National Health and Medical Research Foundation of Australia (project grant number 1079739).