Journal article
Adenosine 2A receptors modulate reward behaviours for methamphetamine
R Chesworth, RM Brown, JH Kim, C Ledent, AJ Lawrence
Addiction Biology | Published : 2016
DOI: 10.1111/adb.12225
Abstract
Addiction to methamphetamine (METH) is a global health problem for which there are no approved pharmacotherapies. The adenosine 2A (A2A) receptor presents a potential therapeutic target for METH abuse due to its modulatory effects on striatal dopamine and glutamate transmission. Notably, A2A receptor signalling has been implicated in the rewarding effects of alcohol, cocaine and opiates; yet, the role of this receptor in METH consumption and seeking is essentially unknown. Therefore, the current study used A2A knockout (KO) mice to assess the role of A2A in behaviours relevant to METH addiction. METH conditioned place preference was absent in A2A KO mice compared with wild-type (WT) litterma..
View full abstractGrants
Funding Acknowledgements
This work was supported by a project grant (1022201) from the National Health and Medical Research Council of Australia. A.J.L. is an NHMRC Principal Research Fellow; R.M.B. is an NHMRC Doherty Fellow; R.C. has an NHMRC Dora Lush scholarship; J.H.K. is an Australian Research Council DECRA Fellow. R.C. also acknowledges support from Rotary Health Australia, as well as The Alan and Elizabeth Finkel Foundation. We acknowledge the Victorian Government's Operational Infrastructure Support Program. We would also like to thank the Florey Behaviour Core Facility.