Journal article

Cohort Profile: The HealthNuts Study: Population prevalence and environmental/genetic predictors of food allergy

Jennifer J Koplin, Melissa Wake, Shyamali C Dharmage, Melanie Matheson, Mimi LK Tang, Lyle C Gurrin, Terry Dwyer, Rachel L Peters, Susan Prescott, Anne-Louise Ponsonby, Adrian J Lowe, Katrina J Allen

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2015

Abstract

HealthNuts is a single-centre, multi-wave, population-based longitudinal study designed to assess prevalence, determinants, natural history and burden of allergy (particularly food allergy) in the early years of life. It is novel in the use of serial food challenge measures within its population frame to confirm food allergy. The cohort comprises 5276 children initially recruited at age 12 months from council-run immunization sessions across Melbourne, Australia. As well as parent-completed questionnaires and researcher-observed eczema status, all infants underwent skin-prick testing to egg, peanut, sesame and either cow's milk or shellfish, and those with detectable wheals underwent food ch..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by US Department of Defence


Funding Acknowledgements

HealthNuts is funded by the National Health and Medical Research Council of Australia [APP491233 and APP1006215], the Ilhan Food Allergy Foundation, AnaphylaxiStop, the Victorian Government's Operational Infrastructure Support Program and the Charles and Sylvia Viertel Medical Research Foundation. Additional funding for follow-up of egg-allergic children at age 2 years was obtained from the Australian Egg Corporation, and funding for a genome-wide association study was obtained from the US Department of Defence [W81XWH-10-1-0487].