Journal article
Investigating the genetics of hippocampal volume in older adults without dementia
KA Mather, NJ Armstrong, W Wen, JB Kwok, AA Assareh, A Thalamuthu, S Reppermund, K Duesing, MJ Wright, D Ames, JN Trollor, H Brodaty, PR Schofield, PS Sachdev
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Hippocampal atrophy is observed with ageing and age-related neurodegenerative disease. Identification of the genetic correlates of hippocampal volume (HV) and atrophy may assist in elucidating the mechanisms of ageing and age-related neurodegeneration. Using two community cohorts of older Caucasians we estimated the heritability of HV and examined associations of HV with previously identified single nucleotide polymorphisms (SNPs). In addition we undertook genome-association studies (GWAS) examining HV and HV atrophy. Participants were community-dwelling non-demented older adults from the longitudinal Sydney Memory and Ageing Study (Sydney MAS) (N = 498) and the Older Australian Twins Study ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a number of sources. Sydney MAS was supported by the Australian National Health and Medical Research Council (NHMRC) Program Grants 350833 and 568969. OATS is supported by the NHMRC/Australian Research Council Strategic Award 401162 and NHMRC Project Grant 1045325. OATS was facilitated through access to the Australian Twin Registry, a national research resource supported by the NHMRC Enabling Grant 310667, administered by the University of Melbourne. OATS genotyping was partly funded by a Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund Grant. DNA was extracted by Genetic Repositories Australia, an Enabling Facility supported by the NHMRC Grant 401184. Henry Brodaty is supported by the Australian Government funded Dementia Collaborative Research Centre (DCRC), UNSW. Amelia Assareh was supported by a PhD scholarship from the DCRC. Nicola Armstrong is supported by the NHMRC Project Grant 525453 and Karen Mather is supported by an Alzheimer's Australia Dementia Research Foundation Postdoctoral Fellowship. Both Simone Reppermund and Karen Mather are supported by the NHMRC Capacity Building Grant 568940. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.