Temporal lobe epilepsy caused by mesial temporal sclerosis and temporal neocortical lesions: A clinical and electroencephalographic study of 46 pathologically proven cases

Abstract

This study aims to determine whether there are important clinico-electrical differences between patients with temporal lobe epilepsy (TLE) secondary to mesial temporal sclerosis (MTS) and those with TLE secondary to a discrete temporal neocortical lesion (NL). The case histories, interictal EEG, seizure semiology, ictal EEG and postoperative outcome of 46 pathologically proven patients (31 MTS and 15 NL) were compared. A history of febrile convulsions (FC) was more common in MTS patients (58% versus 26%, P < 0.05), as was a history of a significant cerebral event at <4 years of age (22% versus 0%, P < 0.05). There were no statistically significant differences in the incidence or nature of au..