Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health
Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker
PROTEIN SCIENCE | WILEY | Published : 2015
The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 Å resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
Grant sponsor: National Health and Medical Research Council Fellowship (MWP).