Journal article

Characterization of G2P[4] rotavirus strains causing outbreaks of gastroenteritis in the Northern Territory, Australia, in 1999, 2004 and 2009

Celeste M Donato, Daniel Cowley, Nicole C Donker, Nada Bogdanovic-Sakran, Thomas L Snelling, Carl D Kirkwood

Infection Genetics and Evolution | ELSEVIER | Published : 2014

Abstract

Outbreaks of rotavirus diarrhea cause a large disease burden in the Alice Springs region of the Northern Territory, Australia. The introduction of the rotavirus vaccine Rotarix® has been associated with an increase in detection of G2P[4] strains in many countries. However, G2P[4] emergence has also been observed in vaccine-naive countries, suggesting a general global increase in the circulation of G2P[4] strains. A G2P[4] rotavirus outbreak occurred in 2009, 28 months after the introduction of the Rotarix® vaccine and 43 children were hospitalized. Pre-vaccine introduction, G2P[4] strains were observed associated with large outbreaks in 1999 and 2004. To determine the genetic relationship be..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by NHMRC Frank Fenner Early Career Research Fellowship


Funding Acknowledgements

C.D. Kirkwood is director of Australian Rotavirus Surveillance Program, which is supported by research grants from vaccine manufacturers CSL, GSK and Merck. This work was supported by grants from the National Health and Medical Research Council of Australia [1031473]; Australian Commonwealth Department of Health; GSK Biologicals (Melbourne, Australia); and CSL (Melbourne, Australia). CD Kirkwood is supported by a Career Development Award from the National Health and Medical Research Council of Australia [607347]. This study was supported by the Victorian Government's Operational Infrastructure Support Program. T. L. Snelling is supported by a NHMRC Frank Fenner Early Career Research Fellowship (1036229) and by a Fiona Stanley Investigator Award. This study was supported by the Victorian Government's Operational Infrastructure Support Program.