A novel role for GSK3 in the regulation of the processes of human labour
Ratana Lim, Martha Lappas
REPRODUCTION | BIOSCIENTIFICA LTD | Published : 2015
Preterm birth remains the largest single cause of neonatal death and morbidity. Infection and/or inflammation are strongly associated with preterm delivery. Glycogen synthase kinase 3 (GSK3) is known to be a crucial mediator of inflammation homeostasis. The aims of this study were to determine the effect of spontaneous human labour in foetal membranes and myometrium on GSK3α/β expression, and the effect of inhibition of GSK3α/β on pro-labour mediators in foetal membranes and myometrium stimulated with Toll-like receptor (TLR) ligands and pro-inflammatory cytokines. Term and preterm labour in foetal membranes was associated with significantly decreased serine phosphorylated GSK3α and β expres..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Associate Professor M Lappas is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC; grant number 1047025). Dr R Lim was, in part, supported by an early career researcher grant from the University of Melbourne. Additional funding was provided from the Medical Research Foundation for Women and Babies.