Journal article

CESA TRAFFICKING INHIBITOR Inhibits Cellulose Deposition and Interferes with the Trafficking of Cellulose Synthase Complexes and Their Associated Proteins KORRIGAN1 and POM2/CELLULOSE SYNTHASE INTERACTIVE PROTEIN1

Natasha Worden, Thomas E Wilkop, Victor Esteva Esteve, Richard Jeannotte, Rahul Lathe, Samantha Vernhettes, Bart Weimer, Glenn Hicks, Jose Alonso, John Labavitch, Staffan Persson, David Ehrhardt, Georgia Drakakaki

Plant Physiology | AMER SOC PLANT BIOLOGISTS | Published : 2015


Cellulose synthase complexes (CSCs) at the plasma membrane (PM) are aligned with cortical microtubules (MTs) and direct the biosynthesis of cellulose. The mechanism of the interaction between CSCs and MTs, and the cellular determinants that control the delivery of CSCs at the PM, are not yet well understood. We identified a unique small molecule, CESA TRAFFICKING INHIBITOR (CESTRIN), which reduces cellulose content and alters the anisotropic growth of Arabidopsis (Arabidopsis thaliana) hypocotyls. We monitored the distribution and mobility of fluorescently labeled cellulose synthases (CESAs) in live Arabidopsis cells under chemical exposure to characterize their subcellular effects. CESTRIN ..

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University of Melbourne Researchers


Awarded by National Science Foundation

Awarded by Deutsch Forschungsgemeinschaft

Awarded by Division Of Integrative Organismal Systems

Awarded by Div Of Molecular and Cellular Bioscience

Funding Acknowledgements

This work was supported by the National Science Foundation (grant nos. IOS-1258135 to G.D., DGE-0653984 to N.W., and DBI-0820755 to J.A.) and by the Deutsch Forschungsgemeinschaft (grant nos. PE1642/5-1 and DAAD [A/10/75281] to S.P. and R.L.).