Journal article
Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI)
JP Tung, JF Fraser, M Nataatmadja, KI Colebourne, AG Barnett, KM Glenister, AY Zhou, P Wood, CC Silliman, YL Fung
Critical Care | Published : 2012
DOI: 10.1186/cc11178
Abstract
Introduction: Critical care patients frequently receive blood transfusions. Some reports show an association between aged or stored blood and increased morbidity and mortality, including the development of transfusion-related acute lung injury (TRALI). However, the existence of conflicting data endorses the need for research to either reject this association, or to confirm it and elucidate the underlying mechanisms.Methods: Twenty-eight sheep were randomised into two groups, receiving saline or lipopolysaccharide (LPS). Sheep were further randomised to also receive transfusion of pooled and heat-inactivated supernatant from fresh (Day 1) or stored (Day 42) non-leucoreduced human packed red b..
View full abstractGrants
Funding Acknowledgements
The authors thank the administrative, animal handling and veterinary staff at MERF for their kind assistance, and Kimble Dunster for his help in setting up data collection protocols. The authors also thank the Australian Red Cross Blood Service staff for their assistance in collecting and processing the PRBC, in particular Margaret Hester, Viktor Klajic and John Walton. The authors acknowledge Australian governments that fully fund the Australian Red Cross Blood Service for the provision of blood products and services to the Australian community. This study was co-funded by the Prince Charles Hospital Research Foundation, the Critical Care Research Group and the University of Queensland.