Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties In Vivo
Markus Muellner, Sarah J Dodds, Nguyen Tri-Hung, Danielle Senyschyn, Christopher JH Porter, Ben J Boyd, Frank Caruso
ACS NANO | AMER CHEMICAL SOC | Published : 2015
Studies of spherical nanoengineered drug delivery systems have suggested that particle size and mechanical properties are key determinants of in vivo behavior; however, for more complex structures, detailed analysis of correlations between in vitro characterization and in vivo disposition is lacking. Anisotropic materials in particular bear unknowns in terms of size tolerances for in vivo clearance and the impact of shape and rigidity. Herein, we employed cylindrical polymer brushes (CPBs) to answer questions related to the impact of size, length and rigidity on the in vivo behavior of PEGylated anisotropic structures, in particular their pharmacokinetics and biodistribution. The modular gra..View full abstract
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Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council under the Australian Laureate Fellowship scheme
This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) scheme. M.M. acknowledges The University of Melbourne for a McKenzie Fellowship.