Journal article

The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis

Fabian Yuh Shiong Kong, Sepehr N Tabrizi, Christopher Kincaid Fairley, Lenka A Vodstrcil, Wilhelmina M Huston, Marcus Chen, Catriona Bradshaw, Jane S Hocking

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2015

Abstract

BACKGROUND: There are increasing concerns about treatment failure following treatment for rectal chlamydia with 1 g of azithromycin. A systematic review and meta-analysis was conducted to investigate the efficacy of 1 g of azithromycin as a single dose or 100 mg of doxycycline twice daily for 7 days for the treatment of rectal chlamydia. METHODS: Medline, Embase, PubMed, Cochrane Controlled Trials Register, Australia New Zealand Clinical Trial Register and ClinicalTrials.gov were searched to the end of April 2014. Studies using 1 g of azithromycin or 7 days of doxycycline for the treatment of rectal chlamydia were eligible. Gender, diagnostic test, serovar, symptomatic status, other sexually..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Senior Research Fellowship


Funding Acknowledgements

This study was carried out as part of our routine work. F. Y. S. K. is supported by an Australian Postgraduate Award, J. S. H. is supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1042907).