Assessment of retinal function and morphology in aging Ccl2 knockout mice

KA Vessey; M Waugh; AI Jobling; JA Phipps; T Ho; L Trogrlic; U Greferath; EL Fletcher

Journal article

Assessment of retinal function and morphology in aging Ccl2 knockout mice

KA Vessey, M Waugh, AI Jobling, JA Phipps, T Ho, L Trogrlic, U Greferath, EL Fletcher

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2015

DOI: 10.1167/iovs.14-15334

Abstract

PURPOSE. The chemokine Ccl2, or monocyte chemoattractant protein-1 (MCP-1), has previously been identified as playing a potential role in many ocular diseases; however, its role in mice is less clear. We sought to correlate changes in retinal pigment epithelium (RPE) and retinal morphology with changes in function in aging Ccl2-/- mice. METHODS. Ccl2-/- mice on a C57BL6J background were genotyped for Crb1rd8/rd8 and were free of this mutation. Ccl2-/- mice and wild-type (WT) C57BL6J mice were investigated for changes in the retinal fundus and histology as a function of age. The function of the rod and cone pathways, and the rate of dark adaptation, was assessed using the electroretinogram (E..

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University of Melbourne Researchers

Kirstan Vessey Author

Andrew Jobling Author

Una Greferath Author

Erica Fletcher Author

Related Projects (1)

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by the National Health and Medical Research Council #APP1061418 (ELF/AIJ) and #APP1061419 (ELF/KV), the American Health Assistance Foundation grant (ELF), and a Victoria's Science Agenda grant (ELF).