PPAR delta activation attenuates hepatic steatosis in Ldlr(-/-) mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity
Lazar A Bojic, Dawn E Telford, Morgan D Fullerton, Rebecca J Ford, Brian G Sutherland, Jane Y Edwards, Cynthia G Sawyez, Robert Gros, Bruce E Kemp, Gregory R Steinberg, Murray W Huff
The Journal of Lipid Research | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014
Awarded by Canadian Institutes of Health Research
Awarded by Heart and Stroke Foundation of Canada
This work was primarily supported by the Canadian Institutes of Health Research Grant MOP-126045 (M.W.H.); the Heart and Stroke Foundation of Canada Grant PRG-5967 (M.W.H.); and the University of Western Ontario, Department of Medicine Grant POEM (M.W.H.). Additional support was provided by grants from the Canadian Diabetes Association (G.R.S.) and the Canadian Foundation for Innovation (G.R.S., R.G.). Creation of Ampk beta 1<SUP>-/-</SUP> mice was supported by grants from the National Health and Medical Research Council (B.E.K., G.R.S.) and the Victorian Government's Operational Infrastructure Support Program (B.E.K.). L. A. Bojic held an Ontario Graduate Scholarship.