Journal article
Reverse cardiac remodeling after renal denervation: Atrial electrophysiologic and structural changes associated with blood pressure lowering
AJA McLellan, MP Schlaich, AJ Taylor, S Prabhu, D Hering, L Hammond, P Marusic, J Duval, Y Sata, A Ellims, M Esler, K Peter, J Shaw, A Walton, JM Kalman, PM Kistler
Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2015
Abstract
Background Hypertension is the most common modifiable risk factor associated with atrial fibrillation. Objective The purpose of this study was to determine the effects of blood pressure (BP) lowering after renal denervation on atrial electrophysiologic and structural remodeling in humans. Methods Fourteen patients (mean age 64 ± 9 years, duration of hypertension 16 ± 11 years, on 5 ± 2 antihypertensive medications) with treatment-resistant hypertension underwent baseline 24-hour ambulatory BP monitoring, echocardiography, cardiac magnetic resonance imaging, and electrophysiologic study. Electrophysiologic study included measurements of P-wave duration, effective refractory periods, and condu..
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Funding Acknowledgements
Drs. McLellan, Prahbu, and Ellims are supported by co-funded NHMRC/NHF Postgraduate Scholarships and Baker IDI Bright Sparks scholarships. Drs. Schlaich and Peter are supported by NHMRC project grants and NHMRC research fellowships. Dr. Taylor is supported by an NHMRC project grant. Dr. Kistler is supported by a practitioner fellowship from the NHMRC. This research is supported in part by the Victorian Government's Operational Infrastructure Funding. Dr. Schlaich has received research support from Medtronic.