Journal article
Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension
Norhafiza Razali, Renu Agarwal, Puneet Agarwal, Sunil Kumar, Minaketan Tripathy, Sushil Vasudevan, Jonathan G Crowston, Nafeeza M Ismail
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | WILEY | Published : 2015
DOI: 10.1111/ceo.12375
Abstract
BACKGROUND: Steroid-induced ocular hypertension is currently treated in the same way as primary open-angle glaucoma. However, the treatment is often suboptimal and is associated with adverse effects. We evaluated the oculohypotensive effects of topical trans-resveratrol in rats with steroid-induced ocular hypertension and involvement of adenosine receptors (AR) in intraocular pressure (IOP) lowering effect of trans-resveratrol. METHODS: The oculohypotensive effect of unilateral single-drop application of various concentrations of trans-resveratrol was first studied in oculonormotensive rats. Concentration with maximum effect was similarly studied in rats with steroid-induced ocular hypertens..
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Awarded by Ministry of Higher Education of Malaysia
Funding Acknowledgements
Funding sources: This study was supported by the Ministry of Higher Education of Malaysia under grant numbers 600-RMI/ST/FRGS.5/3/Fst(50/2011) and 600-RMI/RAGS 5/3 (104/2013).