Journal article

Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension

Norhafiza Razali, Renu Agarwal, Puneet Agarwal, Sunil Kumar, Minaketan Tripathy, Sushil Vasudevan, Jonathan G Crowston, Nafeeza M Ismail

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | WILEY | Published : 2015

Abstract

BACKGROUND: Steroid-induced ocular hypertension is currently treated in the same way as primary open-angle glaucoma. However, the treatment is often suboptimal and is associated with adverse effects. We evaluated the oculohypotensive effects of topical trans-resveratrol in rats with steroid-induced ocular hypertension and involvement of adenosine receptors (AR) in intraocular pressure (IOP) lowering effect of trans-resveratrol. METHODS: The oculohypotensive effect of unilateral single-drop application of various concentrations of trans-resveratrol was first studied in oculonormotensive rats. Concentration with maximum effect was similarly studied in rats with steroid-induced ocular hypertens..

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