Journal article

Regular Transition Zone Biopsy during Active Surveillance for Prostate Cancer May Improve Detection of Pathological Progression

Lih-Ming Wong, Ants Toi, Theodorus Van der Kwast, Greg Trottier, Shabbir MH Alibhai, Narhari Timilshina, Andrew Evans, Alexandre Zlotta, Neil Fleshner, Antonio Finelli

JOURNAL OF UROLOGY | ELSEVIER SCIENCE INC | Published : 2014

Abstract

PURPOSE: We investigated the frequency of cancer and pathological progression in transition zone biopsies in men undergoing multiple rebiopsies while on active surveillance. MATERIALS AND METHODS: Eligibility criteria of the active surveillance prostate cancer database (1997 to 2012) at our tertiary center includes prostate specific antigen 10 ng/ml or less, cT2 or less, no Gleason grade 4 or 5, 3 or fewer positive cores, no core with greater than 50% involvement, patient age 75 years or less and 1 or more biopsies after initial diagnostic biopsy. We excluded from analysis men with fewer than 10 cores at diagnostic biopsy and/or confirmatory biopsy greater than 24 months after diagnostic bio..

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University of Melbourne Researchers