Journal article

Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43

Magdalena Sarasin-Filipowicz, Xueya Wang, Ming Yan, Francois HT Duong, Valeria Poli, Douglas J Hilton, Dong-Er Zhang, Markus H Heim

Molecular and Cellular Biology | AMER SOC MICROBIOLOGY | Published : 2009

Abstract

Recombinant alpha interferon (IFN-alpha) is used for the treatment of viral hepatitis and some forms of cancer. During these therapies IFN-alpha is injected once daily or every second day for several months. Recently, the long-acting pegylated IFN-alpha (pegIFN-alpha) has replaced standard IFN-alpha in therapies of chronic hepatitis C because it is more effective, supposedly by inducing a long-lasting activation of IFN signaling pathways. IFN signaling in cultured cells, however, becomes refractory within hours, and little is known about the pharmacodynamic effects of continuously high IFN-alpha serum concentrations. To investigate the behavior of the IFN system in vivo, we repeatedly inject..

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University of Melbourne Researchers

Grants

Awarded by Swiss National Science foundation


Awarded by Swiss Cancer League


Awarded by Krebsliga Basel


Awarded by National Institutes of Health


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This study was supported by Swiss National Science foundation grant 320000-116106, Swiss Cancer League grant KLS-01832-02-2006, Krebsliga Basel grant 8/05, and National Institutes of Health grant HL091549 (D.-E. Z.),as well as by a grant from the Roche Research Foundation (M.S.-F.).