Journal article

Suppressors of cytokine signaling: Relevance to gastrointestinal function and disease

CJ Greenhalgh, ME Miller, DJ Hilton, PK Lund

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2002

Abstract

BACKGROUND & AIMS: The suppressor of cytokine signaling (SOCS) proteins are a family of Src homology 2 domain-containing proteins. Currently, there are 8 members of the SOCS family, of which a number have been implicated strongly in the negative regulation of cytokine signal transduction pathways. METHODS: This review focuses on recent discoveries about 4 SOCS family members, SOCS-1, -2, and -3, and cytokine-inducible SH2-domain containing (CIS), and provides more limited information about other SOCS family members. RESULTS: A large number of cytokines and growth factors are now known to induce SOCS proteins. In turn, SOCS inhibit the actions of a growing number of cytokines and growth facto..

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University of Melbourne Researchers