Conference Proceedings

Efficacy of Electrical Stimulation of Retinal Ganglion Cells with Temporal Patterns Resembling Light-Evoked Spike Trains

Raymond CS Wong, David J Garrett, David B Grayden, Michael R Ibbotson, Shaun L Cloherty

2014 36TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | IEEE | Published : 2014

Abstract

People with degenerative retinal diseases such as retinitis pigmentosa lose most of their photoreceptors but retain a significant proportion (~30%) of their retinal ganglion cells (RGCs). Microelectronic retinal prostheses aim to bypass the lost photoreceptors and restore vision by directly stimulating the surviving RGCs. Here we investigate the extent to which electrical stimulation of RGCs can evoke neural spike trains with statistics resembling those of normal visually-evoked responses. Whole-cell patch clamp recordings were made from individual cat RGCs in vitro. We first recorded the responses of each cell to short sequences of visual stimulation. These responses were converted to train..

View full abstract