The NAD( )-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

James G Ryall; Stefania Dell'Orso; Assia Derfoul; Aster Juan; Hossein Zare; Xuesong Feng; Daphney Clermont; Miroslav Koulnis; Gustavo Gutierrez-Cruz; Marcella Fulco; Vittorio Sartorelli

Journal article

The NAD( )-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

James G Ryall, Stefania Dell'Orso, Assia Derfoul, Aster Juan, Hossein Zare, Xuesong Feng, Daphney Clermont, Miroslav Koulnis, Gustavo Gutierrez-Cruz, Marcella Fulco, Vittorio Sartorelli

Cell Stem Cell | CELL PRESS | Published : 2015

DOI: 10.1016/j.stem.2014.12.004

University of Melbourne Researchers

James Ryall Author Physiology

Related Projects (1)

CJ MARTIN OVERSEAS BIOMEDICAL FELLOWSHIP - UNDERSTANDING THE MECHANISMS OF MUSCLE GROWTH AND REPAIR

Skeletal muscle regeneration following injury is a tightly regulated process and any disturbance to this process, such as that which occurs ..

Grants

Funding Acknowledgements

We thank Yansong Gu (University of Washington, Seattle) for sharing the Sirt1 floxed mice, Kristina Zaal (Light Imaging Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIAMS]) for help in evaluating Pax7<SUP>+</SUP>/MyoD<SUP>+</SUP> immunofluorescence staining, and Jim Simone (Flow Cytometry Section, NIAMS) for help with FACS. J.G.R. was supported, in part, via an Overseas Biomedical Research Fellowship from the National Health & Medical Research Council of Australia. This work was supported by the Intramural Research Program of NIAMS at the NIH.