Journal article
Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks
Yi Ju, Jiwei Cui, Markus Muellner, Tomoya Suma, Ming Hu, Frank Caruso
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2015
DOI: 10.1021/bm5017139
Abstract
Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly proc..
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Grants
Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by Australian Research Council under the Australian Laureate Fellowship
Awarded by Australian Research Council under the Super Science Fellowship
Funding Acknowledgements
This work was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036). This work was also supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Super Science Fellowship (F.C., FS110200025) schemes. M.M. acknowledges The University of Melbourne for a McKenzie Fellowship. Deconvolution imaging was performed by Benjamin Hibbs at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne. We thank Dr. Kristian Kempe, Dr. Huanli Sun, Dr. Julia Braunger, and Junling Guo for helpful discussions.