Journal article

The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions

Sophie Whish, Katarzyna M Dziegielewska, Kjeld Mollgard, Natassya M Noor, Shane A Liddelow, Mark D Habgood, Samantha J Richardson, Norman R Saunders

FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2015

Abstract

In the adult the interface between the cerebrospinal fluid and the brain is lined by the ependymal cells, which are joined by gap junctions. These intercellular connections do not provide a diffusional restrain between the two compartments. However, during development this interface, initially consisting of neuroepithelial cells and later radial glial cells, is characterized by "strap" junctions, which limit the exchange of different sized molecules between cerebrospinal fluid and the brain parenchyma. Here we provide a systematic study of permeability properties of this inner cerebrospinal fluid-brain barrier during mouse development from embryonic day, E17 until adult. Results show that at..

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