Journal article

THIMEROSAL BLOCKS STIMULATED BUT NOT BASAL RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR (EDRF) IN DOG ISOLATED CORONARY-ARTERY

P CRACK, T COCKS

BRITISH JOURNAL OF PHARMACOLOGY | STOCKTON PRESS | Published : 1992

Abstract

1. The effect of an acetly-coA lysolecithin acyltransferase inhibitor, thimerosal, on the release of endothelium-derived relaxing factor (EDRF) was examined in the greyhound isolated coronary artery. 2. Thimerosal (1-10 microM) relaxed fully, ring segments of coronary artery which were contracted with the thromboxane A2-mimetic, U46619 (30 nM). The response was endothelium-dependent, slow in both onset and time to reach maximum. The maximum relaxation to the highest concentration of thimerosal (10 microM) was maintained for 10-20 min before the tissue slowly regained active force (1-2 h) to the same or higher level as that prior to the addition of thimerosal. At this time the endothelium-dep..

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