Journal article
The contrasting phylodynamics of human influenza B viruses
D Vijaykrishna, EC Holmes, U Joseph, M Fourment, YCF Su, R Halpin, RTC Lee, YM Deng, V Gunalan, X Lin, TB Stockwell, NB Fedorova, B Zhou, N Spirason, D Küuhnert, V Bošková, T Stadler, AM Costa, DE Dwyer, QS Huang Show all
Elife | Published : 2015
DOI: 10.7554/eLife.05055
Abstract
A complex interplay of viral, host and ecological factors shape the spatio-temporal incidence and evolution of human inuenza viruses. Although considerable attention has been paid to inuenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for inuenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of inuenza B virus (Victoria and Yamagata), showing that their individual d..
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Awarded by National Institute of General Medical Sciences
Funding Acknowledgements
This study was supported in part by contracts HHSN266200700005C, HHSN272200900007C and HHSN272201400006C from the National Institute of Allergy and Infectious Disease, National Institutes of Health, Department of Health and Human Services, USA. The Melbourne WHO Collaborating Centre for Reference and Research on Infuenza is supported by the Australian Government Department of Health and Ageing (DV, YMD, SS, ACH, GJDS, IGB). DV, UJ, YCFS and GJDS are supported by the Duke-NUS Signature Research Program funded by the Agency of Science, Technology and Research, Singapore and the Ministry of Health, Singapore and the National Medical Research Council, Singapore (NMRC/GMS/1251/2010) and DV by the Singapore Ministry of Education Academic Research Fund grant (MOE2011-T2-2-049). ECH was supported by an NHMRC Australia Fellowship and grant R01 GM080533 from the National Institutes of Health. RTCL, VG and SM-S are supported by the Agency of Science, Technology and Research (A*STAR), Singapore. ACH and SM-S are additionally supported by NHMRC Australia and A*STAR Singapore joint grant 12/1/06/24/5793. DK, VB and TS thank the Swiss National Science Foundation for funding.