Journal article
IGFBP-2 - taking the lead in growth, metabolism and cancer
SW Yau, WJ Azar, MA Sabin, GA Werther, VC Russo
Journal of Cell Communication and Signaling | Published : 2015
Abstract
The activity of the Insulin-like Growth Factors (IGFs) ligands elicited via their receptors and transduced by various intracellular signal pathways is modulated by the IGF Binding Proteins (IGFBPs). Among all the IGFBPs, IGFBP-2 has been implicated in the regulation of IGF activity in most tissue and organs. Besides binding to IGFs in the circulation these IGF-regulatory activities of IGFBP-2 involve interactions with components of the extracellular matrix, cell surface proteoglycans and integrin receptors. In addition to these local peri-cellular activities, IGFBP-2 exerts other key functions within the nucleus, where IGFBP-2 directly or indirectly promotes transcriptional activation of spe..
View full abstractGrants
Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grant, #1008062) awarded to GAW and VCR. MAS is supported through a National Health and Medical Research Council Professional Training Fellowship (APP1012201). SWY is a recipient of an Australian Postgraduate Award scholarship. We also wish to acknowledge the generous support from the Murdoch Childrens Research Institute and the Royal Children's Hospital Foundation to GAW, MAS and VCR. We also like to thank the Victorian Government Operational Infrastructure Support Program.