Journal article

DIVERSE VASCULAR-RESPONSES TO SEROTONIN IN THE CONSCIOUS RABBIT - EFFECTS OF SEROTONIN ANTAGONISTS ON RENAL-ARTERY SPASM

CE WRIGHT, JA ANGUS

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT-RAVEN PUBL | Published : 1987

Abstract

Vascular conductance in the mesenteric, hindquarter, and renal beds of the conscious rabbit was derived from regional blood flow (pulsed Doppler flowmeter) and ear artery pressure. After autonomic ganglion blockade (mecamylamine), serotonin (5-HT, 5-hydroxytryptamine) infusion, 3-60 micrograms/kg/min i.v., dilated the mesenteric and hindquarter beds but caused renal blood flow to fall to zero. Angiography confirmed that serotonin had caused the conduit renal arteries to spasm. This response was unaltered by 1 mg/kg prazosin but was antagonised by 0.5 mg/kg ketanserin and 0.5 mg/kg methysergide. Only the latter drug shifted the dilator-response curves in the other two beds. Methiothepin, 1 mg..

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