Journal article

RELEASE OF ENDOTHELIUM-DERIVED RELAXING FACTOR FROM RESISTANCE ARTERIES IN HYPERTENSION

JA ANGUS, AC DYKE, GL JENNINGS, PI KORNER, K SUDHIR, JE WARD, CE WRIGHT

KIDNEY INTERNATIONAL | BLACKWELL SCIENCE INC | Published : 1992

Abstract

Aortic rings from SHR are reported to have a decreased relaxation response to the endothelium-dependent agent acetylcholine compared with rings from WKY rats. Thus, a reduced EDRF (nitric oxide) response could contribute to hypertension. We found that in mesenteric small resistance arteries (200 microns I.D.) taken from 5- to 50-week old rats and mounted in a Mulvany-Halpern myograph, that the concentration-response curves to acetylcholine were similar in range and sensitivity (EC50) in arteries from SHR and WKY rats at the same age. Similarly, in small resistance arteries from human buttock skin, the relaxation to acetylcholine was not different between vessels from normotensive volunteers ..

View full abstract