Journal article

Examining potential drug therapies for muscular dystrophy utilising the dy/dy mouse: I. Clenbuterol

A Hayes, DA Williams

JOURNAL OF THE NEUROLOGICAL SCIENCES | ELSEVIER SCIENCE BV | Published : 1998

Abstract

As a potent promoter of muscle growth, clenbuterol has been proposed as a treatment for muscle wasting diseases. Thus, the effects of clenbuterol on dystrophic skeletal muscle was examined. Male dystrophic (dy/dy) mice aged 4-5 weeks were treated with clenbuterol for 3 weeks, and the isometric contractile, fatigue and histochemical properties of the slow-twitch soleus and fast-twitch plantaris muscles measured. Muscles of dystrophic animals produced lower forces, contracted more slowly and exhibited greater fatigue resistance than age-matched normal animals. Dystrophic soleus muscles also had higher proportions of type I fibres than normal mice. Clenbuterol significantly reduced the natural ..

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University of Melbourne Researchers