Journal article

SEROLOGICAL EVALUATION OF THE MACROFILARICIDAL EFFECTS OF DIETHYLCARBAMAZINE TREATMENT IN BANCROFTIAN FILARIASIS

KP DAY, R SPARK, P GARNER, A RAIKO, JD WENGER, N WEISS, GF MITCHELL, MP ALPERS, JW KAZURA

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | AMER SOC TROP MED & HYGIENE | Published : 1991

Abstract

An Mr 200,000 phosphorylcholine-containing antigen (PC-Ag) of predominantly adult worm origin was found in the sera of humans infected with Wuchereria bancrofti. This paper describes results of a longitudinal study of changes in levels of PC-Ag in response to diethylcarbamazine (DEC) therapy as measured by two-site immunoradiometric assay (IRMA) and Western blotting. One hundred thirty-two residents of a bancroftian filariasis-endemic area of Papua New Guinea (PNG) were treated with a 72 mg/kg dose of DEC. A macrofilaricidal effect was seen with this dose of DEC as 34% of the treated subjects had localized side effects and long-term decreases in microfilariae (mf) counts were observed 12 mon..

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