Journal article

2 POPULATIONS OF WOMEN WITH HIGH AND LOW SPLEEN RATES LIVING IN THE SAME AREA OF MADANG, PAPUA NEW GUINEA, DEMONSTRATE DIFFERENT IMMUNE-RESPONSES TO MALARIA

BJ BRABIN, L BRABIN, G CRANE, KP FORSYTH, MP ALPERS, HJ VANDERKAAY

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | ROYAL SOC TROPICAL MEDICINE | Published : 1989

Abstract

Specific malaria and total IgM antibody responses were measured in 2 linguistically distinct coastal Papua New Guinean populations living in the same endemic malarious area, but exhibiting different adult female spleen rates (51% and 30%), in order to establish whether the higher spleen rates in the former group were due to hyper-reactive malarious splenomegaly (HMS). Malaria parasite rates were comparable, and geometric mean titres of IgG malaria antibody were the same, in both groups, indicating comparable exposure to malaria. A higher mean total IgM was observed in the high spleen (HS) rate group (6.07 g/litre, compared with 4.62 g/litre), a higher proportion was seropositive for IgM anti..

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University of Melbourne Researchers