Journal article

ALPHA-2-ADRENOCEPTOR-MEDIATED AUTOINHIBITION OF SYMPATHETIC TRANSMITTER RELEASE IN GUINEA-PIG VAS-DEFERENS STUDIED BY INTRACELLULAR AND FOCAL EXTRACELLULAR RECORDING OF JUNCTION POTENTIALS AND CURRENTS

JA BROCK, TC CUNNANE, K STARKE, CF WARDELL

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | SPRINGER | Published : 1990

Abstract

Excitatory junction potentials (e.j.ps; intracellular electrodes) and excitatory junction currents (e.j.cs; extracellular electrodes) elicited by stimulation (20 pulses at 1 Hz every minute) of the hypogastric nerve trunk were recorded from guinea-pig isolated vas deferens. Intracellular recording. At a variety of stimulation intensities, bath-applied yohimbine (0.1-1 mumol/l) did not change the first one to three e.j.ps in a train but increased the amplitude of subsequent e.j.ps. The effect of yohimbine was abolished in tissues from reserpine-pretreated guinea pigs. Bath-applied desipramine (0.1 mumol/l) diminished the amplitude of all but the first one to three e.j.ps in a train.--Extracel..

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