Journal article

LOCAL APPLICATION OF DRUGS TO SYMPATHETIC-NERVE TERMINALS - AN ELECTROPHYSIOLOGICAL ANALYSIS OF THE ROLE OF PREJUNCTIONAL ALPHA-ADRENOCEPTORS IN THE GUINEA-PIG VAS-DEFERENS

JA BROCK, TC CUNNANE

BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 1991

Abstract

1. Focal extracellular recording techniques were used to study the effects of clonidine, yohimbine and tyramine on the intermittent transmitter release mechanism in the guinea-pig vas deferens in vitro. Drugs were applied locally to the varicosities located within the recording electrode. Statistical methods were used to determine whether noradrenaline (NA) acts locally to inhibit secretion from the same or a closely related release site (local regulation) on an impulse-to-impulse basis. 2. The alpha-adrenoceptor agonist, clonidine, inhibited transmitter release, an effect reversed by the alpha-adrenoceptor antagonist, yohimbine. Yohimbine alone increased action potential-evoked transmitter ..

View full abstract

University of Melbourne Researchers