Journal article

STUDIES ON THE MODE OF ACTION OF BRETYLIUM AND GUANETHIDINE IN POST-GANGLIONIC SYMPATHETIC-NERVE FIBERS

JA BROCK, TC CUNNANE

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | SPRINGER | Published : 1988

Abstract

1. The effects of bretylium and guanethidine on the nerve terminal impulse and transmitter release from sympathetic postganglionic nerve terminals in the guinea-pig vas deferens have been studied in vitro using focal extracellular recording. Excitatory junction currents (EJCs) were used as a measure of transmitter release. 2. Both bretylium and guanethidine altered the configuration of the nerve terminal impulse in a manner consistent with their being local anaesthetics. 3. Bretylium (1-3 microM) only completely inhibited transmitter release when impulse propagation in the sympathetic nerve terminal was blocked. 4. In contrast, guanethidine (1-10 microM) could block transmitter release with ..

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University of Melbourne Researchers