Journal article

ELECTRICAL-ACTIVITY AT THE SYMPATHETIC NEUROEFFECTOR JUNCTION IN THE GUINEA-PIG VAS-DEFERENS

JA BROCK, TC CUNNANE

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 1988

Abstract

1. The relationship between the nerve terminal action potential and transmitter release from sympathetic postganglionic nerve terminals has been studied in vitro by focal extracellular recording. 2. In the absence of stimulation, 'spontaneous excitatory junction currents' (SEJCs) were recorded with amplitudes up to 500 microV, durations of 50-80 ms and frequencies of occurrence of 0.3-0.05 Hz; SEJCs of unusually long time course were also observed. The SEJCs were not recorded in tissues pre-treated with 6-hydroxydopamine to destroy sympathetic nerves, were unaffected by tetrodotoxin (TTX), the competitive alpha-adrenoceptor antagonists, prazosin and phentolamine, the irreversible alpha-adren..

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