RELATIONSHIP BETWEEN THE NERVE ACTION-POTENTIAL AND TRANSMITTER RELEASE FROM SYMPATHETIC POSTGANGLIONIC NERVE-TERMINALS

Abstract

At the skeletal neuromuscular junction, electrophysiological methods have provided much useful information about the mechanisms involved in the release of transmitter. At the autonomic neuroeffector junction it has not been possible to carry out similar studies. Here we report a method of extracellular recording which allows simultaneous measurement of both the nerve action potential and transmitter release from postganglionic sympathetic nerve terminals. We have confirmed that release is intermittent, but the importance of this new approach is that the relationship between the nerve terminal action potential and transmitter release can be studied unambiguously for the first time. Thus we ar..