Journal article
In vivo quantification of retinal changes associated with drusen in age-related macular degeneration
J Rogala, B Zanger, N Assaad, EL Fletcher, M Kalloniatis, L Nivison-Smith
Investigative Ophthalmology and Visual Science | Published : 2015
Abstract
PURPOSE. Drusen alters retinal architecture in early age-related macular degeneration (AMD). However, abnormalities also may exist in drusen-free areas of the AMD retina. This study examines retinal thickness above drusen relative to drusen-free areas in the same patient and a normal population.METHODS. Patients with early to intermediate AMD (n ¼ 122) or no disease (n ¼ 30) were examined at the Center for Eye Health. Spectral domain optical coherence tomography (SD- OCT) scans through single, isolated druse (n ¼ 125) or confluent drusen (n ¼ 54) were obtained. The thickness of individual retinal layers was measured above the druse and in a drusen-free area, 150 lm from the drusen edge.RESUL..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Awarded by University of New South Wales Early Career Research Grant
Funding Acknowledgements
Supported in part by research grants from the National Health and Medical Research Council of Australia (#1033224) and the University of New South Wales Early Career Research Grant 2014 (#PS35430). The authors alone are responsible for the content and writing of the paper.