Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice
Michelle CW Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, Tran An, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann
PLoS Genetics | PUBLIC LIBRARY SCIENCE | Published : 2015
Histones package DNA and regulate epigenetic states. For the latter, probably the most important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic cells, replacing canonical H3. Some replication-independent histones, through their ability to incorporate outside S-phase, are functionally important in the very slowly dividing mammalian germ line. Much remains to be learned of H3.3 functions in germ cell development. Histone H3.3 presents a unique genetic paradigm in that two conventional intron-containing genes encode the identical protein. Here, we present ..View full abstract
Awarded by National Health and Medical Research Council
MCWT was supported by a Melbourne Research Scholarship from The University of Melbourne. This work was supported by grants from the National Health and Medical Research Council www.nhmrc.gov.au to JRM (no. 1002316), to MKO (no. 545805) and to LHW (no. 1031866). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.