Epigenome-wide analysis of neonatal CD4( ) T-cell DNA methylation sites potentially affected by maternal fish oil supplementation
Manori Amarasekera, Paul Noakes, Deborah Strickland, Richard Saffery, David J Martino, Susan L Prescott
EPIGENETICS | TAYLOR & FRANCIS INC | Published : 2014
Supplementation of fish oil rich in omega-3 polyunsaturated fatty acids (n-3 PUFA) during pregnancy has been shown to confer favorable health outcomes in the offspring. In a randomized controlled trial, we have previously shown that n-3 PUFA supplementation in pregnancy was associated with modified immune responses and some markers of immune maturation. However, the molecular mechanisms underlying these heritable effects are unclear. To determine whether the biological effects of maternal n-3 PUFA supplementation are mediated through DNA methylation, we analyzed CD4(+) T-cells purified from cryo-banked cord blood samples from a previously conducted clinical trial. Of the 80 mother-infant pai..View full abstract
This work was funded by the National Health and Medical Research Council of Australia. SP is supported by an NHMRC practitioner fellowship, DM is supported by NHMRC early carrier fellowship and RS is funded by an NHMRC Senior Research Fellowship.