Journal article

Childhood 25-OH Vitamin D Levels and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study

Markus Juonala, Atte Voipio, Katja Pahkala, Jorma SA Viikari, Vera Mikkila, Mika Kahonen, Nina Hutri-Kahonen, Antti Jula, David Burgner, Matthew A Sabin, Jukka Marniemi, Britt-Marie Loo, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Costan G Magnussen, Olli T Raitakari

The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2015

Abstract

CONTEXT: Low vitamin D levels in adulthood have been associated with cardiovascular disease. OBJECTIVE: To investigate if low vitamin D levels in childhood are related with increased carotid artery intima-media thickness (IMT) in adulthood. DESIGN, SETTING, AND PARTICIPANTS: The analyses included 2148 subjects from the Cardiovascular Risk in Young Finns Study, aged 3-18 years at baseline (in 1980). Subjects were re-examined at age 30-45 years (in 2007). Childhood levels of 25-hydroxy-vitamin D were measured from stored serum in 2010. MAIN OUTCOME MEASURE: The carotid artery IMT from 2007 was used. RESULTS: When adjusted for age, sex, and childhood risk factors, continuous data of childhood 2..

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Grants

Awarded by Academy of Finland


Awarded by National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship)


Awarded by National Health and Medical Research Senior Research Fellowship


Awarded by National Heart Foundation Future Leader Fellowship


Funding Acknowledgements

This study was financially supported by the Academy of Finland (Grants No. 126 925, 121 584, 124 282, 129 378, 117 797, and 41 071), the Social Insurance Institution of Finland, the Turku University Foundation, Paulo Foundation, Paavo Nurmi Foundation, Juho Vainio Foundation, Sigrid Juselius Foundation, Maud Kuistila Foundation, Research funds from the Kuopio, Turku, and Tampere University Hospitals, the Finnish Foundation of Cardiovascular Research, the Finnish Medical Foundation, the Orion-Farmos Research Foundation, and the Finnish Cultural Foundation. C.G.M. holds a National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship, APP1037559). D.B. holds a National Health and Medical Research Senior Research Fellowship (APP1064629) and National Heart Foundation Future Leader Fellowship (100369). Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The sponsors had no role in preparing the manuscript.