Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia
MT Witkowski, L Cimmino, Y Hu, T Trimarchi, H Tagoh, MD McKenzie, SA Best, L Tuohey, TA Willson, SL Nutt, M Busslinger, I Aifantis, GK Smyth, RA Dickins
Leukemia | NATURE PUBLISHING GROUP | Published : 2015
Awarded by National Health and Medical Research Council of Australia
Awarded by National Institutes of Health
Awarded by ERC Advanced Grant (LymphoControl) from the European Community's Seventh Framework Program
We thank Mathew Salzone, Melanie Salzone, M Dayton, E Lanera, G Dabrowski, P Kennedy, K Stoev, C Smith, L Wilkins, S Brown and WEHI Bioservices staff for mouse work; W Alexander and E Major for ES cell and mouse resources; R Lane, J Corbin and A Keniry for technical assistance; E Viney and J Sarkis at the Australian Phenomics Network Transgenic RNAi service; M Everest and M Tinning at the Australian Genome Research Facility; and W Shi for assistance with exactSNP. We also thank the Children's Oncology Group for primary human T-ALL samples, S Lowe and J Zuber for vectors and D Largaespada for Vav-tTA mice, and also S Lowe, J Zuber, D Izon, N Kershaw and members of the Dickins laboratory for advice and discussions. This work was supported by the National Health and Medical Research Council of Australia Project Grants 575535 and 1024599, Program Grant 490037, Senior Research Fellowship (GKS), Career Development Fellowship (RAD) and Early Career Fellowship (LC). IA was supported by the National Institutes of Health (1RO1CA133379, 1RO1CA105129, 1RO1CA149655, 5RO1CA173636 and 5RO1CA169784), the William Lawrence and Blanche Hughes Foundation, The Leukemia & Lymphoma Society, The V Foundation for Cancer Research and the St Baldrick's Foundation. The work was also funded by Australian Government NHMRC IRIISS, an Australian Research Council Future Fellowship (SLN), Boehringer Ingelheim (MB), an ERC Advanced Grant (291740-LymphoControl) from the European Community's Seventh Framework Program (MB), the Leukaemia Foundation of Australia (scholarship to MW, fellowship to MDM), a Sylvia and Charles Viertel Charitable Foundation Fellowship (RAD), Victorian State Government OIS grants and a Victorian Endowment for Science, Knowledge and Innovation (VESKI) Fellowship (RAD).