Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants
David Martino, Thanh Dang, Alexandra Sexton-Oates, Susan Prescott, Mimi LK Tang, Shyamali Dharmage, Lyle Gurrin, Jennifer Koplin, Anne-Louise Ponsonby, Katrina J Allen, Richard Saffery
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2015
BACKGROUND: The diagnosis of food allergy (FA) can be challenging because approximately half of food-sensitized patients are asymptomatic. Current diagnostic tests are excellent makers of sensitization but poor predictors of clinical reactivity. Thus oral food challenges (OFCs) are required to determine a patient's risk of reactivity. OBJECTIVE: We sought to discover genomic biomarkers of clinical FA with utility for predicting food challenge outcomes. METHODS: Genome-wide DNA methylation (DNAm) profiling was performed on blood mononuclear cells from volunteers who had undergone objective OFCs, concurrent skin prick tests, and specific IgE tests. Fifty-eight food-sensitized patients (aged 11..View full abstract
Awarded by CASS Foundation
Awarded by DHB Foundation
Awarded by NHMRC
Supported by the CASS Foundation (SM/11/3647/RMR:DSA), the DHB Foundation (CT21242), and the NHMRC (1072752).