Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children
Sarah McNab, Robert S Ware, Kristen A Neville, Karen Choong, Mark G Coulthard, Trevor Duke, Andrew Davidson, Tavey Dorofaeff
Cochrane Database of Systematic Reviews | WILEY | Published : 2014
BACKGROUND: Maintenance intravenous fluids are frequently used in hospitalised children who cannot maintain adequate hydration through enteral intake. Traditionally used hypotonic fluids have been associated with hyponatraemia and subsequent morbidity and mortality. Use of isotonic fluid has been proposed to reduce complications. OBJECTIVES: To establish and compare the risk of hyponatraemia by systematically reviewing studies where isotonic is compared with hypotonic intravenous fluid for maintenance purposes in children.Secondly, to compare the risk of hypernatraemia, the effect on mean serum sodium concentration and the rate of attributable adverse effects of both fluid types in children...View full abstract
External sourcesMurdoch Childrens Research Institute, Australia.Vincent Fairfax Family Foundation Research Entry Scholarship, Royal Australasian College of Physicians, Australia.