Journal article

The utility and limitations of F-18-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: single institution experience and literature review

Chan Y Cheah, Michael S Hofman, John F Seymour, David S Ritchie, Michael Dickinson, Andrew Wirth, H Miles Prince, Max Wolf, Elchanan H Januszcewicz, Dennis A Carney, Kirsten E Herbert, Simon J Harrison, Kate L Burbury, Constantine S Tam

Leukemia & Lymphoma | TAYLOR & FRANCIS LTD | Published : 2015

Abstract

There are limited data regarding the role of (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT) scanning in primary mediastinal B-cell lymphoma (PMBL). We analyzed 28 patients with PMBL treated with chemotherapy, of whom 25 (89%) also received rituximab and 17 (61%) radiotherapy. PET-CT scans were interpreted using visual analysis and a 5-point scale. After a median follow-up of 2.6 years, four patients relapsed and two died. The 2-year progression-free survival and overall survival were 86% and 94%. PET-CT has excellent negative predictive value (interim, 86-87%; end of treatment, 95%) but limited positive predictive value due to the high frequency o..

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