The utility and limitations of F-18-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: single institution experience and literature review
Chan Y Cheah, Michael S Hofman, John F Seymour, David S Ritchie, Michael Dickinson, Andrew Wirth, H Miles Prince, Max Wolf, Elchanan H Januszcewicz, Dennis A Carney, Kirsten E Herbert, Simon J Harrison, Kate L Burbury, Constantine S Tam
Leukemia & Lymphoma | TAYLOR & FRANCIS LTD | Published : 2015
There are limited data regarding the role of (18)F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG PET-CT) scanning in primary mediastinal B-cell lymphoma (PMBL). We analyzed 28 patients with PMBL treated with chemotherapy, of whom 25 (89%) also received rituximab and 17 (61%) radiotherapy. PET-CT scans were interpreted using visual analysis and a 5-point scale. After a median follow-up of 2.6 years, four patients relapsed and two died. The 2-year progression-free survival and overall survival were 86% and 94%. PET-CT has excellent negative predictive value (interim, 86-87%; end of treatment, 95%) but limited positive predictive value due to the high frequency o..View full abstract
Awarded by Victorian Cancer Agency
This work was funded in part by the Victorian Cancer Agency (grant number CTCB11_18) and the Haematology Society of Australia and New Zealand (New Investigator Scholarship).