Journal article

Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA)

Christine M Friedenreich, Sarah MacLaughlin, Heather K Neilson, Frank Z Stanczyk, Yutaka Yasui, Aalo Duha, Brigid M Lynch, Ciara Kallal, Kerry S Courneya

BMC CANCER | BMC | Published : 2014


BACKGROUND: Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically examined how different exercise volumes influence the mechanisms underlying breast cancer etiology. The Breast Cancer and Exercise Trial in Alberta (BETA) - a follow-up study to the Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial - is examining how a one-year, high versus moderate volume aerobic exercise intervention influences several biomechanisms hypothesized to influence breast cancer risk in a group of postmenopausal women. Secondary aims are to compa..

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Awarded by Alberta Cancer Foundation

Awarded by Canadian Cancer Society

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The BETA Trial was funded by a research grant from the Alberta Cancer Foundation (#24404) and the 12-month follow-up was funded by an operating grant from the Canadian Cancer Society (#701000). Dr Christine Friedenreich holds a Health Senior Scholar Award from Alberta Innovates-Health Solutions and the Alberta Cancer Foundation Weekend to End Women's Cancers Breast Cancer Chair. Drs Kerry Courneya and Yutaka Yasui hold Tier I Canada Research Chairs. Dr Lynch is supported by an Early Career Fellowship from the National Health and Medical Research Council (#586727). The authors would like to acknowledge the contribution of Qinggang Wang for the randomization procedures, sample size calculations and description of statistical methods.