Journal article

Fundus Autofluorescence Characteristics of Nascent Geographic Atrophy in Age-Related Macular Degeneration

Zhichao Wu, Chi D Luu, Lauren N Ayton, Jonathan K Goh, Lucia M Lucci, William C Hubbard, Jill L Hageman, Gregory S Hageman, Robyn H Guymer

Investigative Ophthalmology & Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2015

Abstract

PURPOSE: We examined the fundus autofluorescence (FAF) characteristics of nascent geographic atrophy (nGA), pathological features preceding the development of drusen-associated atrophy in eyes with age-related macular degeneration (AMD) that can be visualized using high-resolution optical coherence tomography (OCT). METHODS: Spectral-domain OCT (SD-OCT) and FAF imaging were performed longitudinally in 221 eyes with intermediate AMD (having at least drusen >125 μm), and seven areas that developed drusen-associated atrophy in five eyes were examined and categorized with respect to FAF characteristics. These categories then were used to characterize 49 areas of nGA or drusen-associated atrophy ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC; Canberra, Australia) Project


Awarded by NHMRC practitioner fellowship


Awarded by National Institutes of Health (NIH)


Awarded by NHMRC Centre for Clinical Research Excellence Award


Awarded by NATIONAL EYE INSTITUTE


Funding Acknowledgements

Supported by National Health and Medical Research Council (NHMRC; Canberra, Australia) Project Grant 1027624, NHMRC practitioner fellowship #529905 (RHG), a Macular Degeneration Foundation research grant (GSH and RHG), BrightFocus Foundation, The Menzies Foundation, National Institutes of Health (NIH; Bethesda, MD, USA) Grant R24 EY017404 (GSH), and an unrestricted grant to the University of Utah John A. Moran Eye Center, and Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness, Inc. Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government and is supported by an NHMRC Centre for Clinical Research Excellence Award (#529923).